Therapy of experimental herpes simplex keratitis.

Topical therapy with trypsin, chymotrypsin, and monoxychloroserene, and corneal scrub with iodine, ether, and silver nitrate did not demonstrably reduce the incidence of a positive virus culture from rabbit corneas infected with herpes simplex. It is suggested that the virucidal properties of such substances as measured by their effect on cell-free virus suspensions is not pertinent to the abolition of infection from primary experimental dendritic keratitis, and may not be an important consideration in the therapy of this condition.